General Information

    • DRAMP ID

    • DRAMP04210

    • Peptide Name

    • Adepantin-1 (Automatically Designed Peptide antibacterial 1; synthetic)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIGKHVGKALKGLKGLLKGLGES

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.19947578] Gram-negative bacteria: Escherichia coli ATCC (MIC=2-4 μM), Pseudomonas aeruginosa (MIC=16 μM).

    • Hemolytic Activity

      • [Ref.19947578] HC50>800 μM against human red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membranes

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04210 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04210.

Physicochemical Information

    • Formula

    • C102H182N30O27

    • Absent Amino Acids

    • CDFMNPQRTWY

    • Common Amino Acids

    • G

    • Mass

    • 2260.75

    • PI

    • 10.18

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +5

    • Boman Index

    • -0.67

    • Hydrophobicity

    • -0.013

    • Aliphatic Index

    • 118.7

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP04210

DRAMP04210 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram negative bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Computational design of highly selective antimicrobial peptides.

    • Reference

    • J Chem Inf Model. 2009 Dec;49(12):2873-82

    • Author

    • Juretić D, Vukicević D, Ilić N, Antcheva N, Tossi A.