General Information

    • DRAMP ID

    • DRAMP04531

    • Peptide Name

    • Urechistachykinin II (UII)

    • Source

    • Urechis unicinctus

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AAGMGFFGAR

    • Sequence Length

    • 10

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.18570895] Gram-negative bacteria: Escherichia coli O-157 (MIC=12.7μM), Pseudomonas aeruginosa (MIC=12.7μM), Vibrio vulnificu (MIC=25.4μM) ;
      • Gram-positive bacteria: Streptococcus mutans (MIC=12.7μM), Staphylococcus aureus (MIC=25.4μM),Enterococcus faecium(MIC=25.4μM) ;
      • Fungi: Candida albicans(MIC=25.4μM), Trichosporon beigelii (MIC=12.7μM), Malassezia furfur (MIC=50.9μM).

    • Hemolytic Activity

      • [Ref.18570895] Has no hemolytic activities against human erythrocyte cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04531 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C44H65N13O11S

    • Absent Amino Acids

    • CDEHIKLNPQSTVWY

    • Common Amino Acids

    • AG

    • Mass

    • 984.14

    • PI

    • 9.79

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +1

    • Boman Index

    • 1.64

    • Hydrophobicity

    • 0.72

    • Aliphatic Index

    • 30

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP04531

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Antifungal. Has no hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial effect and membrane-active mechanism of Urechistachykinins, neuropeptides derived from Urechis unicinctus.

    • Reference

    • FEBS Lett. 2008 Jul 9;582(16):2463-2466.

    • Author

    • Sung WS, Park SH, Lee DG.