General Information

    • DRAMP ID

    • DRAMP04543

    • Peptide Name

    • Polybia-MP-II (insects, vertebrates, animals)

    • Source

    • Polybia paulista (Neotropical social wasp)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • IDWLKLGKMVIDAL

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Cytotoxic

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=5 µM), Pseudomonas aeruginosa (MIC=38 µM).
      • Gram-positive bacteria: Staphylococcus aureus (MIC=2 µM), Bacillus cereus (MIC=5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • It forms amphipathic alpha-helical conformations under membrane-mimetic conditions.

    • Helical Wheel Diagram

    • DRAMP04543 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04543.

Physicochemical Information

    • Formula

    • C76H127N17O19S

    • Absent Amino Acids

    • CEFHNPQRSTY

    • Common Amino Acids

    • L

    • Mass

    • 1615.01

    • PI

    • 5.96

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • 0

    • Boman Index

    • 7.53

    • Hydrophobicity

    • 0.871

    • Aliphatic Index

    • 167.14

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 1

DRAMP04543

Comments Information

    • Function

    • Both peptides (Polybia-MP-II and -III) are polyfunctional, causing pronounced cell lysis of rat mast cells and erythrocytes, in addition to having antimicrobial activity against both Gram-positive and Gram-negative bacteria.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista.

    • Reference

    • Peptides. 2009 Aug;30(8):1387-1395.

    • Author

    • de Souza BM, da Silva AV, Resende VM, Arcuri HA, Dos Santos Cabrera MP, Ruggiero Neto J, Palma MS.