• • DRAMP ID

  • DRAMP18115

• • Peptide Name

  • C-C motif chemokine 7 (Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3;

• • Source

  • Homo sapiens (Human)

• • Family

  • Belongs to the intercrine beta (chemokine CC) family

• • Gene

  • CCL7

• • Sequence

  • QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWV

• • Sequence Length

  • 60

• • UniProt Entry

  • P80098,Q569J6

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antitumor

• • Target Organism

  • No MICs found in DRAMP database

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • 14% helical (1 helices; 11 residues)

• • Structure Description

  • The shape of the MCP-3 monomer is that of an elongated tetrahedral. It consists of a three-stranded antiparallel β sheet and a three turn C-terminal α helix lying above the sheet floor. The N-terminal extremity is disordered up to residue 12, but located close to the helix; it consists of a long mobile loop, spatially stabilized because of the two disulfide bonds which link Cys 11 with Cys 36 and Cys 12 with Cys 52.

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 1BO0,1NCV resolved by NMR

• Predicted Structure

• There is no predicted structure for DRAMP18115.

DRAMP18115

• • Function

  • Chemotactic factor that attracts monocytes and eosinophils, but not neutrophilS. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.##PTM

• ·Literature 1

• • Title

  • Human monocyte chemotactic protein-3 (MCP-3): molecular cloning ofthe cDNA and comparison with other chemokineS.

• • Pubmed ID

  • 8461011

• • Reference

  • BiocheM. BiophyS. ReS. Commun. 191:535-542 (1993).

• • Author

  • Opdenakker G., Froyen G., Fiten P., Proost P., van Damme J.

• ·Literature 2

• • Title

  • The human MCP-3 gene (SCYA7): cloning, sequence analysis, andassignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.

• • Pubmed ID

  • 7916328

• • Reference

  • Genomics 21:403-408 (1994).

• • Author

  • Opdenakker G., Fiten P., Nys G., Froyen G., van Roy N., Speleman F., Laureys G., van Damme J.

• ·Literature 3

• • Title

  • Molecular cloning of the MCP-3 chemokine gene and regulation of its expression.

• • Pubmed ID

  • 8318676

• • Reference

  • Eur. Cytokine Netw. 4:99-110 (1993).

• • Author

  • Minty A., Chalon P., Guillemot J.-C. , Kaghad M. , Liauzun P., Magazin M. , Miloux B., Minty C. , Ramond P., Vita N., Lupker J., Shire D., Ferrara P., Caput D.

• ·Literature 4

• • Title

  • The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).

• • Pubmed ID

  • 15489334

• • Reference

  • Genome ReS. 14:2121-2127 (2004).

• • Author

  • The MGC Project Team

• ·Literature 5

• • Title

  • Structural and functional identification of two human, tumor-

• • Pubmed ID

  • 1613466

• • Reference

  • J. Exp. Med. 176:59-65 (1992).

• • Author

  • van Damme J., Proost P., Lenaerts J.-P., Opdenakker G.

• ·Literature 6

• • Title

• • Pubmed ID

  • 15340161

• • Reference

  • Protein Sci. 13:2819-282

• • Author

  • Zhang Z., Henzel W.J.