General Information

    • DRAMP ID

    • DRAMP18120

    • Peptide Name

    • BnPRP1 (Plant defensin)

    • Source

    • Brassica napus

    • Family

    • Gene

    • BnPRP1

    • Sequence

    • PPTQNPSMAPPTQNPYGQPMTPPTQNPYGQPMAPP

    • Sequence Length

    • 35

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive: M. luteus (MIC= 16.9 ± 2.7 uM );
      • Gram-negative: E. coli (MIC= 8.4 ± 1.4 uM);
      • Fungi:Sclerotinia sclerotiorum, Mucor sp., Magnaporthe oryzae and Botrytis cinerea

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18120 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18120.

Physicochemical Information

    • Formula

    • C164H245N43O51S3

    • Absent Amino Acids

    • CDEFHIKLRVW

    • Common Amino Acids

    • P

    • Mass

    • 3731.19

    • PI

    • 5.95

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • 0

    • Boman Index

    • -4903

    • Hydrophobicity

    • -1.329

    • Aliphatic Index

    • 5.71

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 87.65

    • Polar Residues

    • 12

DRAMP18120

DRAMP18120 chydropathy plot

Comments Information

    • BnPRP1 has 40.5% identity with a known proline-rich antimicrobial peptide SP-B from the pig. BnPRP1 isolated from B. napus was the first PR-AMP member that was characterized in plants, and its homology sequences were found in some other Brassicaceae plants by the genome sequences analysis.

Literature Information

  • ·Literature 1

    • Title

    • Identification of a Novel Proline-Rich Antimicrobial Peptide from Brassica napus.

    • Reference

    • PLoS One. 2015 Sep 18;10(9):e0137414.

    • Author

    • Cao H, Ke T, Liu R, et al.