General Information

    • DRAMP ID

    • DRAMP18198

    • Peptide Name

    • Chaxapeptin

    • Source

    • Streptomyces leeuwenhoekii Strain C58

    • Family

    • Not found

    • Gene

    • ls3A sle2_130

    • Sequence

    • GFGSKPLDSFGLNFF

    • Sequence Length

    • 15

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer

    • Target Organism

    • S. aureus and B. subtilis (MIC 30-35 ug/mL)

    • Hemolytic Activity

      • Not found

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • 2N5C resolved by NMR
    • DRAMP18198 helical wheel diagram

Physicochemical Information

    • Formula

    • C79H109N17O21

    • Absent Amino Acids

    • ACEHIMQRTVWY

    • Common Amino Acids

    • F

    • Mass

    • 1632.84

    • PI

    • 5.84

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • 0

    • Boman Index

    • -313

    • Hydrophobicity

    • 0.233

    • Aliphatic Index

    • 52

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP18198

Comments Information

    • Function

    • Active against Gram-positive strains, S. aureus and B. subtilis (MIC 30-35 ug/mL), and no activity against the Gram-negative bacteria. It also showed dose dependent inhibition of A549 cancer cells.

Literature Information

  • ·Literature 1

    • Title

    • Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert.

    • Reference

    • J Org Chem.80(20):10252-60(2015)

    • Author

    • Elsayed SS, Trusch F, Deng H, Raab A, Prokes I, Busarakam K, Asenjo JA, Andrews BA, van West P, Bull AT, Goodfellow M, Yi Y, Ebel R, Jaspars M, Rateb ME.