General Information

    • DRAMP ID

    • DRAMP18198

    • Peptide Name

    • Chaxapeptin

    • Source

    • Streptomyces leeuwenhoekii Strain C58

    • Family

    • Unknow

    • Gene

    • ls3A sle2_130

    • Sequence

    • GFGSKPLDSFGLNFF

    • Sequence Length

    • 15

    • Evidence code

Activity Information

    • Biological Activity

    • Anti-Gram+, Anticancer

    • Target Organism

      • S. aureus and B. subtilis (MIC 30-35 ug/mL)

    • Hemolytic activity

    • Unknown

    • Binding Traget

    • Unknow

Structure Information

    • Structure

    • Unknow

    • Structure Description

    • Unknow

    • PDB ID

    • 2N5C resolved by NMR
    • DRAMP18198 helical wheel diagram

Physical Information

    • Formula

    • C79H109N17O21

    • Absent Amino Acids

    • ACEHIMQRTVWY

    • Common Amino Acids

    • F

    • Mass

    • 188272

    • PI

    • 6.34

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Boman Index

    • -313

    • Hydrophobicity

    • 23.33

    • Aliphatic Index

    • 52

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

Amino Acid Distribution

Comments Information

    • Function

    • Active against Gram-positive strains, S. aureus and B. subtilis (MIC 30-35 ug/mL), and no activity against the Gram-negative bacteria. It also showed dose dependent inhibition of A549 cancer cells.

Literature Information

  • Literature 1

    • Reference

    • J Org Chem.80(20):10252-60(2015)

    • Author

    • Elsayed SS, Trusch F, Deng H, Raab A, Prokes I, Busarakam K, Asenjo JA, Andrews BA, van West P, Bull AT, Goodfellow M, Yi Y, Ebel R, Jaspars M, Rateb ME.

    • Title

    • Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert.