• DRAMP ID

    • DRAMP18198
    • Peptide Name

    • Chaxapeptin
    • Source

    • Streptomyces leeuwenhoekii Strain C58
    • Family

    • Unknow
    • Gene

    • ls3A sle2_130
    • Sequence

    • GFGSKPLDSFGLNFF
    • Sequence Length

    • 15
    • Evidence code

    • Biological Activity

    • Anti-Gram+, Anticancer
    • Target Organism

      • S. aureus and B. subtilis (MIC 30-35 ug/mL)
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • 2N5C resolved by NMR
    • DRAMP18198 helical wheel diagram
    • Formula

    • C79H109N17O21
    • Absent Amino Acids

    • ACEHIMQRTVWY
    • Common Amino Acids

    • F
    • Mass

    • 188272
    • PI

    • 6.34
    • Basic Residues

    • 1
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 6
    • Boman Index

    • -313
    • Hydrophobicity

    • 23.33
    • Aliphatic Index

    • 52
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 6
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Amino Acid Distribution

    • Function

    • Active against Gram-positive strains, S. aureus and B. subtilis (MIC 30-35 ug/mL), and no activity against the Gram-negative bacteria. It also showed dose dependent inhibition of A549 cancer cells.
  • Literature 1
    • Reference

    • J Org Chem.80(20):10252-60(2015)
    • Author

    • Elsayed SS, Trusch F, Deng H, Raab A, Prokes I, Busarakam K, Asenjo JA, Andrews BA, van West P, Bull AT, Goodfellow M, Yi Y, Ebel R, Jaspars M, Rateb ME.
    • Title

    • Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert.