General Information

    • DRAMP ID

    • DRAMP18226

    • Peptide Name

    • Gageostatin A (Bacteriocin)

    • Source

    • Bacillus subtilis

    • Family

    • Belongs to the lipopeptides family

    • Gene

    • Not found

    • Sequence

    • LLDVLLE

    • Sequence Length

    • 7

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

    • Gram-positive, Gram-negative

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Leu-Leu-Asp-Val-Leu-Leu-Glu-3-beta-hydroxy-11-methyltridecanoic acid

    • Helical Wheel Diagram

    • DRAMP18226 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18226.

Physicochemical Information

    • Formula

    • C38H67N7O12

    • Absent Amino Acids

    • ACFGHIKMNPQRSTWY

    • Common Amino Acids

    • L

    • Mass

    • 813.99

    • PI

    • 3.67

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • -2

    • Boman Index

    • 819

    • Hydrophobicity

    • 1.771

    • Aliphatic Index

    • 264.29

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP18226

Comments Information

    • Fuction

    • Surfactin like heptapeptides, cytotoxic. It is noteworthy that these compounds 1

Literature Information

  • ·Literature 1

    • Title

    • Gageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis.

    • Reference

    • Mar Drugs. 2014 Jan 31;12(2):871-85.

    • Author

    • Tareq FS, Lee MA, Lee HS, Lee JS, Lee YJ, Shin HJ.