General Information

    • DRAMP ID

    • DRAMP18362

    • Peptide Name

    • Formicin (bacteriocin)

    • Source

    • Bacillus paralicheniformis APC 1576

    • Family

    • Belongs to the lantibiotic family.

    • Gene

    • Not found

    • Sequence

    • CEWYNISCQLGNKGQWCTLTKECQRSCK

    • Sequence Length

    • 28

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: L. s delbrueckii subsp. bulgaricus, L. amylophilus, L. lactis, M. luteus, S. smutans, including clinical strains S. aureus, C. difficile, and L. monocytogenes.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18362 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18362.

Physicochemical Information

    • Formula

    • C139H217N41O43S5

    • Absent Amino Acids

    • ADFHMPV

    • Common Amino Acids

    • C

    • Mass

    • 3310.8

    • PI

    • 8.4

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +2

    • Boman Index

    • -5947

    • Hydrophobicity

    • -0.821

    • Aliphatic Index

    • 41.79

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 12740

    • Absorbance 280nm

    • 471.85

    • Polar Residues

    • 14

DRAMP18362

DRAMP18362 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Formicin - a novel broad-spectrum two-component lantibiotic produced by Bacillus paralicheniformis APC 1576

    • Reference

    • Microbiology. 2016 Sep;162(9):1662-1671.

    • Author

    • Collins FW, O'Connor PM, O'Sullivan O, Rea MC, Hill C, Ross RP.