General Information

    • DRAMP ID

    • DRAMP18366

    • Peptide Name

    • Sungsanpin (a class 2 lasso peptide; bacteriocins)

    • Source

    • a Marine Streptomyces species

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFGSKPIDSFGLSWL

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Anti-cancer

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Form a lactam bond at position 1 and 8(Gly1, Asp8)

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18366 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18366.

Physicochemical Information

    • Formula

    • C77H111N17O21

    • Absent Amino Acids

    • ACEHMNQRTVY

    • Common Amino Acids

    • GS

    • Mass

    • 1610.83

    • PI

    • 5.84

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • 0

    • Boman Index

    • 140

    • Hydrophobicity

    • 0.28

    • Aliphatic Index

    • 78

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 6

DRAMP18366

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Sungsanpin, a lasso peptide from a deep-sea streptomycete

    • Reference

    • J Nat Prod. 2013 May 24;76(5):873-9

    • Author

    • Um S, Kim YJ, Kwon H, Wen H, Kim SH, Kwon HC, Park S, Shin J, Oh DC.