General Information

    • DRAMP ID

    • DRAMP18403

    • Peptide Name

    • Tridecaptin A1 (TriA1; lipopeptides; nonribosomally synthesized peptide antibiotic)

    • Source

    • Paenibacillus terrae; old: Bacillus circulans NRRL B-30644

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VKGSWSKKFEVIA

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against Gram+ B. subtilis JH642 (MIC 50 uM), S. aureus ATCC 25923 (100 uM), Gram- food pathogens C. jejuni NCTC 11168 (MIC 100 uM), E. coli DH5alpha (MIC 50 uM), and Salmonella enterica serovar Typhimurium (25 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Nonhelixbeta

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18403 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP18403.

Physicochemical Information

    • Formula

    • C70H109N17O17

    • Absent Amino Acids

    • CDHLMNPQRTY

    • Common Amino Acids

    • K

    • Mass

    • 1478.75

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • -920

    • Hydrophobicity

    • -0.043

    • Aliphatic Index

    • 76.43

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 3

DRAMP18403

Comments Information

    • There are three D-type 2,4-diaminobutyrate (Dab), represented by K's here. In addition, residue V1, S4, W5, and I12 are also D-amino acids.

Literature Information

  • ·Literature 1

    • Title

    • Biochemical, structural, and genetic characterization of tridecaptin A?, an antagonist of Campylobacter jejuni.

    • Reference

    • Chembiochem. 2014 Jan 24;15(2):243-9.

    • Author

    • Lohans CT1, van Belkum MJ, Cochrane SA, Huang Z, Sit CS, McMullen LM, Vederas JC.