General Information

    • DRAMP ID

    • DRAMP18507

    • Peptide Name

    • SolyC (Plant defensin; tomato, plants)

    • Source

    • Tomato

    • Family

    • Belongs to the tomato defensin family

    • Gene

    • Not found

    • Sequence

    • FSGGNCRGFRRRCFCTK

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.23124812]Gram-positive bacteria: Staphylococcus aureus A170 (MIC=40 μg/mL), Staphylococcus epidermidis (MIC=40 μg/mL), Listeria monocytogenes (MIC=40 μg/mL);
      • Gram-negative bacteria: Salmonella enterica serovar Paratyphi (MIC=15 μg/mL), Escherichia coli (MIC=15 μg/mL), Helicobacter pylori VB1 (MIC=15 μg/mL), Helicobacter pylori VB2 (MIC=10 μg/mL), Helicobacter pylori VB3 (MIC=15 μg/mL), Helicobacter pylori VB4 (MIC=12 μg/mL), Helicobacter pylori VB5 (MIC=15 μg/mL), Helicobacter pylori VB6 (MIC=10 μg/mL), Helicobacter pylori VB7 (MIC=15 μg/mL), Helicobacter pylori VB8 (MIC=10 μg/mL), Helicobacter pylori VB9 (MIC=10 μg/mL), Helicobacter pylori VB10 (MIC=15 μg/mL).

    • Hemolytic Activity

      • [Ref.23124812]<5% hemolysis at 50 μg/mL against mouse red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Beta sheet

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18507 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18507.

Physicochemical Information

    • Formula

    • C83H131N31O21S3

    • Absent Amino Acids

    • ADEHILMPQVWY

    • Common Amino Acids

    • R

    • Mass

    • 1995.33

    • PI

    • 10.74

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +5

    • Boman Index

    • -6224

    • Hydrophobicity

    • -0.718

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 7.81

    • Polar Residues

    • 9

DRAMP18507

Comments Information

    • Function

    • Antibacterial activity against a panel of human pathogens, including H.pylori, and displays anti-inflammatory activity in vitro. Weak hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • A novel synthetic peptide from a tomato defensin exhibits antibacterial activities against Helicobacter pylori.

    • Reference

    • J Pept Sci. 2012 Dec;18(12):755-62.

    • Author

    • Rigano MM, Romanelli A, Fulgione A, Nocerino N, D'Agostino N, Avitabile C, Frusciante L, Barone A, Capuano F, Capparelli R.