• DRAMP ID

    • DRAMP18507
    • Peptide Name

    • SolyC (Plant defensin; tomato, plants)
    • Source

    • Tomato
    • Family

    • Belongs to the tomato defensin family
    • Gene

    • N/A
    • Sequence

    • FSGGNCRGFRRRCFCTK
    • Sequence Length

    • 17
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • N/A
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.23124812]Gram-positive bacteria: Staphylococcus aureus A170 (MIC=40 μg/mL), Staphylococcus epidermidis (MIC=40 μg/mL), Listeria monocytogenes (MIC=40 μg/mL);
      • Gram-negative bacteria: Salmonella enterica serovar Paratyphi (MIC=15 μg/mL), Escherichia coli (MIC=15 μg/mL), Helicobacter pylori VB1 (MIC=15 μg/mL), Helicobacter pylori VB2 (MIC=10 μg/mL), Helicobacter pylori VB3 (MIC=15 μg/mL), Helicobacter pylori VB4 (MIC=12 μg/mL), Helicobacter pylori VB5 (MIC=15 μg/mL), Helicobacter pylori VB6 (MIC=10 μg/mL), Helicobacter pylori VB7 (MIC=15 μg/mL), Helicobacter pylori VB8 (MIC=10 μg/mL), Helicobacter pylori VB9 (MIC=10 μg/mL), Helicobacter pylori VB10 (MIC=15 μg/mL).
    • Hemolytic Activity

      • [Ref.23124812]<5% hemolysis at 50 μg/mL against mouse red blood cells.
    • Cytotoxicity

    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • Beta sheet
    • Structure Description

    • N/A
    • DRAMP18507 helical wheel diagram
    • Formula

    • C83H131N31O21S3
    • Absent Amino Acids

    • ADEHILMPQVWY
    • Common Amino Acids

    • R
    • Mass

    • 228088
    • PI

    • 11.31
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 3
    • Boman Index

    • -6224
    • Hydrophobicity

    • -71.76
    • Aliphatic Index

    • 0
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 7.81
    • Polar Residues

    • 9

DRAMP18507

    • Function

    • Antibacterial activity against a panel of human pathogens, including H.pylori, and displays anti-inflammatory activity in vitro. Weak hemolytic activity.
  • Literature 1
    • Reference

    • J Pept Sci. 2012 Dec;18(12):755-62.
    • Author

    • Rigano MM, Romanelli A, Fulgione A, Nocerino N, D'Agostino N, Avitabile C, Frusciante L, Barone A, Capuano F, Capparelli R.
    • Title

    • A novel synthetic peptide from a tomato defensin exhibits antibacterial activities against Helicobacter pylori.