General Information

    • DRAMP ID

    • DRAMP18706

    • Peptide Name

    • Pleurain-R1 (Frogs, amphibians, animals)

    • Source

    • Rana pleuraden (Yunnan pond frog)

    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.

    • Gene

    • Not found

    • Sequence

    • CVHWMTNTARTACIAP

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.19028675]Gram-negative bacterium: Escherichia coli (MIC=100 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=25 μg/ml), Bacillus subtilis (MIC=100 μg/ml);
      • Yeast: Candida albicans(MIC=50 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18706 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C75H119N23O21S3

    • Absent Amino Acids

    • DEFGKLQSY

    • Common Amino Acids

    • AT

    • Mass

    • 1775.09

    • PI

    • 8.08

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • -1230

    • Hydrophobicity

    • 0.325

    • Aliphatic Index

    • 61.25

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 375

    • Polar Residues

    • 6

DRAMP18706

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.

Literature Information

  • ·Literature 1

    • Title

    • Antioxidant peptidomics reveals novel skin antioxidant system.

    • Reference

    • Mol Cell Proteomics. 2009 Mar;8(3):571-83.

    • Author

    • Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R.