• DRAMP ID

    • DRAMP18721
    • Peptide Name

    • Hinnavin I (Hin I; insects, arthropods, invertebrates, animals)
    • Source

    • Artogeia rapae (cabbage butterfly)
    • Family

    • Belongs to the Cecropins family.
    • Gene

    • Not found
    • Sequence

    • GWKIGKKLEHHGQNIRDGLISAGPAVFAVGQAATIYAAAK
    • Sequence Length

    • 40
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.9339895] Gram-positive bacteria: Bacillus subtilis (Inhibition zone=3.0 mm), Bacillus megaterium Bm11 (Inhibition zone=5.0 mm), Bacillus thuringiensis (Inhibition zone=3.0 mm);
      • Gram-negative bacteria: Escherichia coli (Inhibition zone=7.0 mm), Escherichia coli D21 (Inhibition zone=7.1 mm), Enterobacter cloacae (Inhibition zone=6.0 mm);
      • Fungi: Candida albicans (Inhibition zone=3.0 mm), Aspergillus niger (Inhibition zone=3.0 mm).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Cell membranes
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18721 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C188H299N55O51
    • Absent Amino Acids

    • CM
    • Common Amino Acids

    • A
    • Mass

    • 4145.78
    • PI

    • 9.82
    • Basic Residues

    • 7
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 18
    • Net Charge

    • +5
    • Boman Index

    • -2277
    • Hydrophobicity

    • -0.013
    • Aliphatic Index

    • 93
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 6990
    • Absorbance 280nm

    • 179.23
    • Polar Residues

    • 10

DRAMP18721

DRAMP18721 chydropathy plot
    • Function

    • Hinnavin 1 is heat stable; its activity is retained after 60 min incubation at 100 DC, being effective against Gram negative and/or Gram positive bacteria. Hinnavin I and lysozyme 2 showed a powerful synergistic effect on the inhibition of bacterial growth.
  • ·Literature 1
    • Title

    • Hinnavin I, an antibacterial peptide from cabbage butterfly, Artogeia rapae.
    • Reference

    • Mol Cells. 1997 Aug 31;7(4):509-13
    • Author

    • Bang IS, Son SY, Yoe SM.