General Information

    • DRAMP ID

    • DRAMP18724

    • Peptide Name

    • Oncorhyncin III (Oncorhyncin-3, histone-derived; fish, animals)

    • Source

    • Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

    • Family

    • Belongs to the HMGN family.

    • Gene

    • Not found

    • Sequence

    • PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAGNAK

    • Sequence Length

    • 69

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.12713443] Gram-positive bacteria: Aerococcus viridans (MIC=0.06-0.12 μM), Bacillus subtilis (MIC=0.25-0.5 μM), Micrococcus luteus (MIC=0.12-0.25 μM), Planococcus citerus (MIC=0.06-0.12 μM);
      • Gram-negative bacteria: Aeromonas hydrophila (MIC>0.5 μM), Aeromonas salmonicida (MIC>0.5 μM), Escherichia coli (MIC=0.25-0.5 μM), Listonella anguillarum (MIC=0.25-0.5 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18724 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C298H520N102O89

    • Absent Amino Acids

    • CFHIMWY

    • Common Amino Acids

    • A

    • Mass

    • 6956.04

    • PI

    • 10.75

    • Basic Residues

    • 20

    • Acidic Residues

    • 6

    • Hydrophobic Residues

    • 23

    • Net Charge

    • +14

    • Boman Index

    • -17896

    • Hydrophobicity

    • -1.139

    • Aliphatic Index

    • 45.8

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 12

DRAMP18724

DRAMP18724 chydropathy plot

Comments Information

    • Function

    • Oncorhyncin III has antibacterial activity against Gram-positive and Gram-negative bacteria at submicromolar concentrations. Non-histone protein that probably binds to the inner side of nucleosomal DNA, altering the association between the DNA and the nucleosome octamer.

Literature Information

  • ·Literature 1

    • Title

    • Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss.

    • Reference

    • Biochem 2003; 373 (Pt 2): 621-628

    • Author

    • Fernandes JM., Saint N, Kemp GD, Smith VJ.