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Sequence Name
- Sequence 6 from Patent US 7244710
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Source
- Synthetic construct
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Activity
- Antimicrobial, Antibacterial, Antifungal
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Patent Type
- Granted Patent
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Publication Date
- 2007-7-17
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Patent Title
- Treatment Of Ophthalmic Infections Using Antimicrobial Peptides
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Abstract
- The present invention discloses a method of treating an ophthalmic infection by administering to a vertebrate inflicted with the ophthalmic infection an ophthalmologically effective amount of an antimicrobial peptide which is derived from alpha-melanocyte-stimulating hormone (alpha-MSH) and biologically functional equivalents thereof. Specifically, the antimicrobial peptides derived from alpha-melanocyte-stimulating hormone (alpha-MSH) include alpha-MSH (1-13) which is SYSMEHFRWGKPV, alpha-MSH (4-10) which is MEHFRWG, alpha-MSH (6-13) which is HFRWGKPV, alpha-MSH (11-13) which is KPV, and a KPV dimer. The ophthalmic infection can be caused by a microorganism which include a bacteria, a fungi or a virus. The vertebrate includes a bird and a mammal. The antimicrobial peptide has anti-bacterial, antifungal, and antiviral property and therefore can be administered at the onset of the ophthalmic infection before the microorganism causing the infection is determined as well as thereafter.