Patent Information

    • DRAMP ID

    • DRAMP18851

    • Sequence

    • NIRRIIRKIIHIIKKY

    • Sequence Length

    • 16

    • Sequence Name

    • Sequence 31 from Patent US 7071293

    • Source

    • Ovis aries

    • Activity

    • Antimicrobial, Antiproliferative

    • Patent Type

    • Granted Patent

    • Publication Date

    • 2006-7-4

    • Patent Title

    • Alpha Helical Peptides With Broad Spectrum Antimicrobial Activity That Are Insensitive To Salt

    • Abstract

    • The present invention relates to the use of antimicrobial peptides in the inhibition of microbial growth and proliferation. Novel antimicrobial truncated peptides are disclosed which are based upon SMAP 29 and RCAP 27, but which contain a lesser number ofmino acid residues yet still retain bactericidal activity. In addition, synthetic peptides based upon the SMAP 29 protein are disclosed which have fewer amino acid residues and include substitutions yet retain substantial activity. The invention also relates to a method of inhibiting microbial growth by administering an effective amount of a peptide in accordance with the invention, or by combining the peptides with other antimicrobial agents or antibiotics.