Patent Information

    • DRAMP ID

    • DRAMP19047

    • Sequence

    • RVWCRRRCYRGFCRYFCR

    • Sequence Length

    • 18

    • Sequence Name

    • Sequence 8 from Patent US 6747007

    • Source

    • Limulus polyphemus

    • Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Patent Type

    • Granted Patent

    • Publication Date

    • 2004-6-8

    • Patent Title

    • Antimicrobial Peptides And Methods Of Use Thereof

    • Abstract

    • A class of cationic, polyphemusinlike peptides having antimicrobial activity is provided. Examples of such peptides include FRWCFRVCYKGRCRYKCR (SEQ ID NO,3), RRWCFRVCYKGFCRYKCR (SEQ ID NO,4), and RRWCFRVCYRGRFCYRKCR (SEQ ID NO,20). Also provided are meths for inhibiting the growth of microbes such as bacteria, yeast and viruses utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.