• DRAMP ID

    • DRAMP21203
    • Peptide Name

    • AmyI-1-18 (Oryza sativa L., Angiospermae, Plants)
    • Source

    • Oryza sativa subsp. japonica (Rice)
    • Family

    • Belongs to the glycosyl hydrolase 13 family.
    • Gene

    • AMY1.1
    • Sequence

    • HLNKRVQRELIGWLDWLK
    • Sequence Length

    • 18
    • Evidence code

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-gram-, Antifungal
    • Target Organism

      • [Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=13±3 μM).
      • [Ref.26850838] Fungi: Candida albicans(IC50=64±2 μM)
    • Hemolytic Activity

      • [Ref.27478151] 0.1% hemolysis at 100 μM against human red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Unknown
    • Linear/Cyclic/Branched

    • Linear
    • N-terminal modification

    • Free
    • C-terminal modification

    • Free
    • Other modifications

    • None
    • Stereochemistry

    • L
    • Structure

    • Alpha helix
    • Structure Description

    • Unknown
    • DRAMP21203 helical wheel diagram
    • Formula

    • C107H170N32O25
    • Absent Amino Acids

    • ACFMPSTY
    • Common Amino Acids

    • L
    • Mass

    • 2304.73
    • PI

    • 9.99
    • Basic Residues

    • 5
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 8
    • Boman Index

    • -3907
    • Hydrophobicity

    • -68.33
    • Aliphatic Index

    • 124.44
    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 11000
    • Absorbance 280nm

    • 647.06
    • Polar Residues

    • 2

DRAMP21203

DRAMP21203 chydropathy plot
    • Function

    • Antibacterial activity against Gram-negative bacteria. Antifungal activity gaginst Candida albicans. Important for breakdown of endosperm starch during germination.
  • Literature 1
    • Reference

    • J Biosci Bioeng. 2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008.
    • Author

    • Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T
    • Title

    • Antimicrobial activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-18 and its amino acid-substituted analogs.
  • Literature 2
    • Reference

    • Biopolymers. 2016 Mar;106(2):219-229. doi: 10.1002/bip.22817.
    • Author

    • Title

    • Effect of alanine, leucine, and arginine substitution on antimicrobial activity against candida albicans and action mechanism of a cationic octadecapeptide derived from α-amylase of rice.