General Information
-
DRAMP ID
- DRAMP21584
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Peptide Name
- 3BA3
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Sequence
- KⓍWKLⓍKAKⓍWKLⓍK
-
Sequence Length
- 15
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Original Sequence
- /
-
Source
- Synthetic construct
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Comments
- Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
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Target Organism
-
- Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC = 2.3 μg/mL), Staphylcocccus aureus ATCC 6538p (MIC = 1.6 μg/mL), Staphylcococcus epidermis ATCC 12228 (MIC = 3.1 μg/mL);
- Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC = 3.1 μg/mL), Shigella dysentariae ATCC 9752 (MIC = 6.3 μg/mL), Salmonella typhimurium ATCC 14028 (MIC = 12.5 μg/mL), Klebsiella pneumonia ATCC 10031 (MIC = 3.1 μg/mL), Pseudomonas aeruginosa ATCC 27853 (MIC = 3.1 μg/mL)
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Hemolytic Activity
-
- It has 14.2% hemolysis against human red blood cells at 6.3 μM and 24.9% hemolysis at 12.5 μM.
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
Structure Information
-
Linear/Cyclic
- Cyclic (Stapled)
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N-terminal Modification
- Acetylation
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C-terminal Modification
- Amidation
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Special Amino Acid and Stapling Position
- ①The A (position: 8) in sequence is β-Ala. ②The Ⓧ (position: 2, 6, 10 and 14) in sequence indicates (S)-α-methyl, α-pentenylglycine. ③Ⓧ (2) and Ⓧ (6), Ⓧ (10) and Ⓧ (14) are cross-linked respectively by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple.
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Stereochemistry
- L
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Secondary Structure
- No specific results about the strcture presented in the forms of tables, graphs or words
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Structure Description
- No other descriptive information about the structure found in the literature
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Helical Wheel Diagram
-
Predicted Structure
- There is no predicted structure for DRAMP21584.
Physicochemical Information
-
Formula
- C₁₀₁H₁₆₅N₂₃O₁₆
Absent Amino Acids
- CDEFGHIMNPQRSTVY
Common Amino Acids
- K
Mass
- 1957.58
PI
- /
-
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 5
Hydrophobicity
- /
Polar Residues
- 0
DRAMP21584
Literature Information
- Literature 1
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Title
- Antimicrobial and Hemolytic Activity of Stapled Heptapeptide Dimers
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Pubmed ID
- PubMed ID is not available
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Reference
- B KOREAN CHEM SOC. 2016 Aug;37(8)1199-1203. doi: 10.1002/bkcs.10839.
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Author
- Huy X Luong, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim