Patent Information

    • DRAMP ID

    • DRAMP28392

    • Sequence

    • DSHAKRHHGYKRRFHEKHHSHRGY

    • Sequence Length

    • 24

    • Sequence Name

    • Sequence 6 from Patent US 10464977

    • Source

    • Synthetic construct

    • Activity

    • Antimicrobial, Antifungal

    • Patent Type

    • Granted Patent

    • Publication Date

    • 2019-11-5

    • Patent Title

    • Histatin-5 Based Synthetic Peptides And Uses Thereof

    • Abstract

    • Provided herein are synthetic peptides or synthetic fragments thereof based on a Histatin-5 peptide, for example with a sequence DSHAKRHHGYKRKFHEKHHSHRGY (SEQ ID NO: 1). The synthetic peptides or synthetic fragments have at least one substituted amino acid that is arginine and/or leucine to increase resistance to proteolytic degradation by a microbe, such as a fungus. The synthetic peptides or synthetic fragments thereof may be contained in a hydrogel. Also provided are methods for treating or preventing a pathophysiological condition via topical administration of the synthetic peptide or fragments. The pathophysiological condition may be a fungal or bacterial infection including associated inflammation or a chronic condition.