General Information

    • DRAMP ID

    • DRAMP29276

    • Peptide Name

    • E1P41-1

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KWESEFWRWTEQLASNYW

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • CC(C)C[C@H](NC(=O)[C@H](CCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O)NC(=O)CC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

Activity Information

    • Biological Activity

    • Antimicrobial,Antiviral

    • Target Organism

      • [Ref.26905802]Virus:
        Target OrganismActivity
        HIV-1 NL4-3:inhibition of virus infection in TZM-bl cellsIC50=66.7 ± 20.2 μM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • gp41

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP29276.

Physicochemical Information

    • Formula

    • C117H152N28O31

    • Absent Amino Acids

    • CDGHIMPV

    • Common Amino Acids

    • W

    • Mass

    • 2446.66

    • PI

    • 4.79

    • Basic Residues

    • 2

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 7

    • Net Charge

    • -1

    • Boman Index

    • -4356

    • Hydrophobicity

    • -1.372

    • Aliphatic Index

    • 27.22

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 23490

    • Absorbance 280nm

    • 1381.76

    • Polar Residues

    • 5

DRAMP29276

Comments Information

    • Function

    • Antiviral activity against Influenza virus.

Literature Information

  • ·Literature 1

    • Title

    • Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor.

    • Reference

    • Biochim Biophys Acta. 2016 Jun;1860(6):1139-48.

    • Author

    • Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I.