General Information
-
DRAMP ID
- DRAMP29351
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Peptide Name
- SAU-1
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Sequence
- ⓧLFDⓧIKKIAESF
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Sequence Length
- 13
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Original Sequence
- GLFDIIKKIAESF
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Source
- Synthetic construct
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Comments
- Function: Antifungal.
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Target Organism
-
- [Ref.34439006]Fungi: C. albicans SC5314(MIC>64 μg/mL), C. albicans 901(MIC=32 μg/mL), C. albicans 904(MIC>128 μg/mL), C. tropicalis ATCC 20026 (MIC>128 μg/mL), C. tropicalis 895 (MIC>128 μg/mL), C. glabrata ATCC 1182 (MIC>128 μg/mL), C. glabrata 896 (MIC>128 μg/mL), C. auris 918 (MIC>128 μg/mL), C. auris 919 (MIC>128 μg/mL), C. krusei ATCC 2340 (MIC>128 μg/mL), C. parapsilosis ATCC 22010(MIC=128 μg/mL).
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Hemolytic Activity
-
- No hemolytic activity information found.
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
Structure Information
-
Linear/Cyclic
- Cyclic (Stapled)
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N-terminal Modification
- Acetylation
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C-terminal Modification
- Amidation
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Special Amino Acid and Stapling Position
- ①The Ⓧ (position: 1 and 5) in sequence indicates S5 (2-amino-2-methylhept-6-enoic acid). ②Ⓧ (1) and Ⓧ (5) are cross-linked by hydrocarbon stapling respectively.
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Stereochemistry
- L
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Secondary Structure
- 60.2% α-helix in a solution of phosphate buffer and trifluoroethanol (7:3) and reached a concentration of 50 μM.
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Structure Description
- No other descriptive information about the structure found in the literature
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Helical Wheel Diagram
-
Predicted Structure
- There is no predicted structure for DRAMP29351.
Physicochemical Information
-
Formula
- C62H92N12O14
Absent Amino Acids
- CHMNPQRSTVWY
Common Amino Acids
- I
Mass
- 1533.22
PI
- 6.07
-
Basic Residues
- 1
Acidic Residues
- 2
Hydrophobic Residues
- 7
Hydrophobicity
- 103.08
Polar Residues
- 1
DRAMP29351
Literature Information
- Literature 1
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Title
- Design, Synthesis and Antifungal Activity of Stapled Aurein1.2 Peptides.
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Pubmed ID
- 34439006
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Reference
- Antibiotics (Basel). 2021 Aug 9;10(8):956.
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Author
- Zheng M, Wang R, Chen S, Zou Y, Yan L, Zhao L, Li X.