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Sequence
- MFTLKKSLLLLFFLGTINLSLCEEERDAEEERRDNPDERDVEVEKRFLPFIARLAAKVFPSIICSVTKKC
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Sequence Name
- Sequence 21 from Patent US 2022/0125873
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Source
- Synthetic construct
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Patent Type
- Patent Application
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Publication Date
- 2022-4-28
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Patent Title
- Antimicrobial Peptides
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Abstract
- Antimicrobial peptides (AMPs), small compounds that often exhibitbroad spectrum antimicrobial activity, are garnering interest as potential therapeutics against antibiotic-resistant bacterial pathogens. Development of new AMPs is arduous due to the practical limitations of classical protein-based discovery approaches. A high throughput bioinformatics approach is described which is able to confirm identification of known AMPs from the North American bullfrog ( Rana ( Lithobates ) catesbeiana ) genome, and a bioinformatics approach is used to develop new AMPs. The described AMPs exhibit antimicrobial activity against Mycobacterium smegmatis via microtitre broth dilution assays, indicating broader efficacy.