• • DRAMP ID

  • DRAMP30631

• • Peptide Name

  • Alloferon (3-13)

• • Source

  • Synthetic construct(derived from Alloferon-1)

• • Family

  • Herpesviridae, Picornaviridae

• • Gene

  • Not found

• • Sequence

  • VSGHGQHGVHG

• • Sequence Length

  • 11

• • UniProt Entry

  • P83412

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antiviral

• • Target Organism

  • • [Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):

      Target Organism	Activity
      inhibition of virus replication in Vero cells(IC50=500 µM);	-

    • HHV-1 clinical strain:

      Target Organism	Activity
      inhibition of virus replication in Hep-2 cells(IC50=117 µM);	-

    • Coxsackie virus B2(clinical strain):

      Target Organism	Activity
      inhibition of virus replication in Hep-2 cells(IC50=38 µM);	-

    • Coxsackie virus 971 PT B2:

      Target Organism	Activity
      inhibition of virus replication in HEp-2 cells(IC50=250 µM);inhibition of virus replication in LLC-MK2 cells	IC50=93 µM

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • [Ref.22883213]No cytotoxic against Vero, Hep-2 and LLC-MK2 cells up to 165 µM.

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP30631.

DRAMP30631

• • Comment

  • No comments found on DRAMP database

• ·Literature 1

• • Title

  • New alloferon analogues: synthesis and antiviral properties.

• • Pubmed ID

  • 22883213

• • Reference

  • Chem Biol Drug Des. 2013 Feb;81(2):302-9.

• • Author

  • Kuczer M, Majewska A, Zahorska R.