General Information

    • DRAMP ID

    • DRAMP30631

    • Peptide Name

    • Alloferon (3-13)

    • Source

    • Synthetic construct(derived from Alloferon-1)

    • Family

    • Herpesviridae, Picornaviridae

    • Gene

    • Not found

    • Sequence

    • VSGHGQHGVHG

    • Sequence Length

    • 11

    • Protein Existence

    • Not found

    • SMILES

    • CC(C)[C@H](N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)O)C(C)C

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):
        Target OrganismActivity
        inhibition of virus replication in Vero cells(IC50=500 µM);-
      • HHV-1 clinical strain:
        Target OrganismActivity
        inhibition of virus replication in Hep-2 cells(IC50=117 µM);-
      • Coxsackie virus B2(clinical strain):
        Target OrganismActivity
        inhibition of virus replication in Hep-2 cells(IC50=38 µM);-
      • Coxsackie virus 971 PT B2:
        Target OrganismActivity
        inhibition of virus replication in HEp-2 cells(IC50=250 µM);inhibition of virus replication in LLC-MK2 cellsIC50=93 µM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.22883213]No cytotoxic against Vero, Hep-2 and LLC-MK2 cells up to 165 µM.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP30631.

Physicochemical Information

    • Formula

    • Absent Amino Acids

    • Common Amino Acids

    • Mass

    • 0

    • PI

    • 0

    • Basic Residues

    • Acidic Residues

    • Hydrophobic Residues

    • Net Charge

    • Boman Index

    • 0

    • Hydrophobicity

    • 0

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:
      • Yeast:
      • E.coli:

    • Extinction Coefficient Cystines

    • Absorbance 280nm

    • 0

    • Polar Residues

DRAMP30631

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • New alloferon analogues: synthesis and antiviral properties.

    • Reference

    • Chem Biol Drug Des. 2013 Feb;81(2):302-9.

    • Author

    • Kuczer M, Majewska A, Zahorska R.