General Information

    • DRAMP ID

    • DRAMP33144

    • Peptide Name

    • Decoralin [AT4]

    • Source

    • Synthetic (Derived from Decoralin)

    • Family

    • Gene

    • Not found

    • Sequence

    • LLLLLIRKLIL

    • Sequence Length

    • 11

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: MCF-7 (EC50=25±1 μM); 1205Lu (EC50=48±1 μM); Jurkat (EC50=50±1 μM); A549 (EC50>100 μM)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • HDMEC: EC50=278±1 μM

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP33144 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP33144.

Physicochemical Information

    • Formula

    • C66H125N15O12

    • Absent Amino Acids

    • ACDEFGHMNPQSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 149939

    • PI

    • 11.65

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 2381

    • Hydrophobicity

    • 2.473

    • Aliphatic Index

    • 319.09

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP33144

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Multidimensional Design of Anticancer Peptides

    • Reference

    • Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10370-4.

    • Author

    • Lin YC, Lim YF, Russo E, Schneider P, Bolliger L, Edenharter A, Altmann KH, Halin C, Hiss JA, Schneider G.