Clinical-Browse

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DRAMP ID	NAME	Description	Medical_use	Stage of development	Company
DRAMP18152	IMX942(Inimex)	Synthetic cationic host defense peptide,derivative of IDR-1 and indolicidin	Treatment for chemotherapeutic induced neutropenia, nosocomial infections	Phase II	Inimex
DRAMP18153	Opebacan	21-amino-acid peptide derivative of bactericidal/permeability-increasing protein	Endotoxemia in hematopoetic, stem cell transplant, recipients	Phase I/II	Xoma
DRAMP18154	XOMA-629	9-amino-acid peptide derivative of bactericidal/permeability-increasing protein	Impetigo	Phase III	Xoma
DRAMP18155	DiaPep277	DiaPep277 is a small, lyophilized powder containing 24 Amino-acids. It has proved in former studies that DiaPep277 can slow down beta cells destruction in the pancreas and therefore decelerate the progress of Diabetes.	Type 1 diabetes mellitus	Phase III	DeveloGen
DRAMP18156	RDP58(Delmitide)	Semisynthetic D-amino acid decapeptide derived from HLA class I B2702	Inflammatory bowel disease	Post Phase II	Genzyme; licensed to Procter&Gamble
DRAMP18157	NVXT (Novexatin, NP213)	cyclic cationic peptide derived from NovaBiotics arginine peptide platform	Onychomycosis (fungal nail infection)	Phase IIb	NovaBiotics
DRAMP18158	PMX-30063(brilacidin)	Defensin structural mimetic, non-peptide,small molecule/copolymer	Acute bacterial skin infections caused by Staphylococcusspp	Phase II	PolyMedix
DRAMP18159	Oritavancin	Oritavancin is a glycopeptide antibiotic used to treat acute bacterial skin and skin structure infections caused by susceptible Gram-positive bacteria. It was developed by The Medicines Company (acquired by Novartis).	Treatment of adult patients with acute bacterial skin and skin structure (including subcutaneous) infection.	In market	The Medicines Company
DRAMP18161	OP-145 (AMP60.4Ac)	Synthetic 24-mer peptide derived from LL-37 for binding to lipopolysaccharides or lipoteichoic acid	Chronic suppurative otitis media (middle ear infections)	Phase II (Completed)	OctoPlus BV, Dr Reddy’s Research and Development BV
DRAMP18162	BL2060	Synthetic compound comprising fatty acid and lysine copolymers	Anti-infective	Lead optimization	BioLineRx (Jerusalem).
DRAMP18163	Ghrelin	Endogenous host-defence peptide,Synthetic construct	Airway inflammation, chronic respiratory infection and cystic fibrosis, cnacer	Phase II (Completed)	University of Miyazaki Third Department of Internal Medicine (Japan) and Papworth Hospital (UK).
DRAMP18164	AP-214(Modimelanotide)	Synthetic derivative from HDP α-melanocyte-stimulating hormone	①Prevention of acute kidney injury after cardiac surgery; ②Treatment of sepsis.	Phase II (Completed)	Action Pharma A/S (Aarhus and Copenhagen, Denmark)
DRAMP18165	CD-NP(Cenderitide)	Synthetic chimeric 37-mer derived from combination of two natriuretic peptides	Acute decompensated failure (ADHF),Organ failure	Phase II	Nile Therapeutics (United States, Minnesota).
DRAMP18166	Vasoactive intestinal peptide (VIP; Endogenous HDP)	No more description	Acute Respiratory Distress Syndrome and Sepsis	Phase I	Stony Brook University and State University of New York (United States, New York).
DRAMP18167	Ruminococcin C (Bacteriocin)	Ruminococcus gnavus E1	Gastrointestinal tract infections; Stomach and intestine infections (Rat model; In-vivo)	Preclinical	Unknown
DRAMP18168	Planosporicin (Bacteriocin)	Planomonospora sp. DSM14920	Hospital-acquired infections; Multi-drug resistant strain (Murine model; In-vivo)	Preclinical	Unknown
DRAMP18169	ESL5	Enterococcus faecalis SL-5	Gastrointestinal tract infections; Stomach and intestine infections (Human model; In-vivo)	Preclinical	Unknown
DRAMP18170	Colicin E1 (Bacteriocin)	Escherichia coli H22	Gastrointestinal tract infections; Stomach and intestine infections (Murine model; In-vivo)	Preclinical	Unknown
DRAMP18171	Lactocin 160 (Bacteriocin)	Lactobacillus rhamnosus 160	Urogenital tract infections; Bacterial vaginosis	Preclinical	Unknown
DRAMP18172	Bacteriocin OR-7	Lactobacillus salivarius NRRL B-30514	Gastrointestinal tract infections; Campylobacter infection (Chicken model; In-vivo)	Preclinical	Unknown