clinical Information

    • DRAMP ID

    • DRAMP18062

    • Sequence

    • αhelix

    • Sequence Name

    • Histatin

    • Description

    • using a variant of histatins, which are naturally occurring cationic peptides in saliva

    • Activity

    • Antifungal(fungal cell membrane,mitochondrion)

    • Medical use

    • chronic Pseudomonas aeruginosa infections

    • Stage of Development

    • Phase I

    • Comments

    • No more comments

    • Company

    • Demgen and Dow Pharmaceutical Sciences;licensed to the Vancouver, Canada, company Pacgen

    • Target Organism

      • Histatins manifest an in vivo IC50 value of approximately 1.4 μM

    • Reference

      • Histatins: antimicrobial peptides with therapeutic potential. J. Pharm. Pharmacol. (2004).(PMID: 15025852)