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Sequence Name
- Talactoferrin(TLF;rhLF)
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Description
- has a structure and properties similar to native human lactoferrin
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Medical use
- Combined with chemotherapy in the first-line treatment of advanced non-small cell lung cancer;Topical treatment in diabetic neutropathic ulcers
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Stage of Development
- Phase III
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- The trial met its primary end point and the addition of oral talactoferrin to carboplatin/paclitaxel enhanced the patients response to chemotherapy on all tumour-related end points, including response rate, progression-free survival, time to response and duration of response(p = 0.05)
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Target Organism
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- No MICs found on DRAMP database
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Reference
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- Antimicrobial peptides: therapeutic potential. Expert Opin. Pharmacother. (2006).
- Oral lactoferrin inhibits growth of established tumours and potentiates conventional chemotherapy. Int. J. Cancer(2004).(PMID: 15221967)
- Phase I trial of oral talactoferrin alfa in refractory solid tumors.Invest. New Drugs(2006).(PMID: 16193240)