• DRAMP ID

    • DRAMP18085
    • Sequence

    • Sequence Name

    • CSA(cationic steroid antibiotics)
    • Description

    • The CSAs share structural features in common with the AMPs that form part of the bodys innate immune system.
    • Activity

    • Unknown
    • Medical use

    • Anti-infective,including multi-drug resistant organisms such as pseudomonas, MRSA and vancomycin-resistant S. aureus
    • Stage of Development

    • Preclinical
    • Comments

    • No more comments
    • Company

    • Ceragenix
    • Target Organism

      • In planktonic cultures, the minimal inhibitory and minimal bactericidal concentrations of CSA-13 were in the 1-25 mg/L range except for one mucoid clinical strain which was much less sensitive to tobramycin (minimal bactericidal concentration, 65-125 mg/L). At concentrations higher than 20 mg/L, it permeabilized the plasma membrane of human umbilical vein endothelial cells.