Sequence Information

    • DRAMP ID

    • DRAMP18092

    • Name

    • PTX002

    • Sequence

    • Description

    • 33-mer peptide;

    • Activity

    • Antibacterial(bacterial membranes)

    • Target Organism

      • Gram-negative bacteria:
        E. coli J5 (MIC90=0.01X10-6 M), E. coli J96 (MIC90=0.1X10-6 M), E. coli H5 (MIC90=0.71X10-6 M), E. coli IA2 (MIC90=0.06X10-6 M), Pseudomonas aeruginosa (MIC90=0.03X10-6 M);
      • Gram-positive bacteria:
        Staphlococcus aureus MN8 (MIC90=0.25X10-6 M), Staphlococcus aureus MNHO (MIC90=0.16X10-6 M).

    • Reference

      • Antimicrobial peptides: therapeutic potential. Expert Opin. Pharmacother. (2006).
      • Design of a potent novel endotoxin antagonist. Surgery(1997).(PMID: 9288144)

Clinical Information

    • Medical use

    • Broad-spectrum antimicrobial;Antiendotoxin

    • Company

    • PepTx

    • Stage of Development

    • Preclinical

    • Comments

    • In addition to targeting bacterial membranes, PTX002 and PTX005 neutralise endotoxin in the blood and may prove effective in treating sepsis.Preliminary studies in mouse infection models, using a lethal dose of P. a e r u g i n o s a, showed a fivefold increase in survival in treated animals (71%) compared with control animals (14%).

    • Clinical Trials