Sequence Information

    • DRAMP ID

    • DRAMP29317

    • Name

    • Colistin(polymyxin-E)

    • Sequence

    • 6-mh-DabTDab[γDablLDabDabT]

    • Description

    • Colistin is a polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.

    • Activity

    • Antibacterial

    • Target Organism

      • No MICs found on DRAMP database

    • Reference

      • Different surface charge of colistin-susceptible and -resistant Acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment.(PMID: 21081544)

Clinical Information

    • Medical use

    • Treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

    • Company

    • Stage of Development

    • In market

    • Comments

    • Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.