Result: 1 - 20 of 96
DRAMP IDNAMEDescriptionMedical_useStage of developmentCompany
DRAMP18057MSI-78(Pexiganan, Locilex)Pexiganan is a broad-spectrum synthetic analogue of the African frog peptide magainin.Infected diabetic foot ulcersPhase III(Failure)Genaera (Plymouth, PA)
DRAMP18058Daptomycin(Cubicin, LY-164032)Daptomycin is a cyclic lipopeptide antibiotic used to treat complicated skin and skin structure infections by susceptible Gram-positive bacteria and bacteremia due to Staphylococcus aureus.Treatment of complicated skin and skin structure infections (cSSSI), Staphylococcus aureus bloodstream infections (bacteremia)In marketCubist Pharmaceuticals LLC (Merck & Co.)
DRAMP18059Iseganan(IB-367)Iseganan is a synthetic analogue of Protegrin I (IBL-367, the pig protegrin derivative), extracted from porcine leukocytes.①Prevention of Ventilator-Associated Pneumonia; ②Prevention of oral complications caused by radiation therapy for head and neck cancer.Phase III(Failure)Intrabiotics Pharmaceuticals Inc.(Mountain View, CA)
DRAMP18060p2TA(AB103, Reltecimod)Reltecimod is under investigation in clinical trial NCT02469857 (Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections).Necrotizing soft tissue infectionsPhase IIIAtox Bio Ltd.
DRAMP18061Histatinusing a variant of histatins, which are naturally occurring cationic peptides in salivaantimicrobial-peptide-containing mouth wash for the treatment of oral candidiasis (gingivitis and periodontal diseases)Phase II-IIIDemgen and Dow Pharmaceutical Sciences;licensed to the Vancouver, Canada, company Pacgen
DRAMP18062Ramoplanin(NTI-851)Ramoplanin(NTI-851) is a macrocyclic glycolipodepsipeptideproduced by Actinoplanesspp. being developed by Nano-therapeutics.It exhibits bactericidal activity by blocking the cell wall peptidoglycansynthesis of gram-positive bacteria. Recently, the phase III clinicalstudy of the peptide was initiated for the oral treatment ofvancomycin-resistantenterococcus(VRE) colonization, as well as the phase II trial against Clostridium difficile.Treatment of bacterial infections.Phase IIINano-therapeutics
DRAMP18063P113a 12 amino acid fragment of histatin 5Reduce gum bleeding, gingivitis and plaquePhase IIDemgen
DRAMP18064P113Da 12 amino acid fragment of histatin 5an inhalation treatment for Pseudomonas aeruginosainfections in cystic fibrosis patientsUnknownDemgen
DRAMP18067Dalbavancin (BI397, Dalvance, Xydalba)Dalbavancin is a semisynthetic lipoglycopeptide and derivate of teicoplanin. It is an antibacterial used to treat acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible strains of Gram-positive bacteria.Acute bacterial skin infections, Osteomyelitis and septic arthritis(Phase IV)In marketAllergan (formerly Actavis and Durata Therapeutics)
DRAMP18068hLF1-11(Human lactoferrin 1-11)hLF1-11 was significantly more effective than the full length protein or the peptide representing the second cationic domain. As with other antimicrobial peptides, hLF1-11 shows poor antimicrobial activity under physiological conditions in vitro, but it is highly effective in vivo against infections due to a variety of microorganisms, including Gram negative and Gram positive bacteria and fungi. The objective is to develop hLF1-11 for the treatment of fungal and bacterial infections that develop during neutropenia that results from myeloablative therapy to prepare for a haematopoietic stem cell transplant(HSCT) formerly referred to as bone marrow transplant. Bacteraemia and fungal infections in immunocompromized haematopoetic stem cell transplant recipientsPhase I-IIAM-Pharma Holding BV
DRAMP18069rBPI21(Neuprex)a human bactericidal permeability protein derivativemeningococcaemia;prophylactic treatment of infectious complications from post-traumatic bleeding (in 842 patients)Phase III(Failure)Xoma Ltd(Berkeley, CA, USA)
DRAMP18070XMP 629(HY-P2170; CS-0109623)extracted from humanImpetigo and acne rosaceaPhase IIIXoma Ltd(Berkeley, CA, USA)
DRAMP18071Mycoprexextracted from insectsFungal infectionsPhase IIIXoma Ltd.
DRAMP18072Heliomocin variants(ETD151)an antifungal 44 amino acid peptide, variant of a natural peptide from lepidopteran Heliothis virescensSystemic fungal infections in immunocompromised patients and multi-resistant bacterial infections PreclinicalEntoMed SA
DRAMP18073PG-1Protegrin ClassTreatment of peritoneal infections caused by P. aeruginosa and S. aureus.Treatment of pneumoniaUnknownIntrabiotics
DRAMP18074CSA-13cationic steroid (ceragenin) that mimics host-defense peptidesAnti-infectivePreclinicalCeragenix(Denver)
DRAMP18075HB-50synthetic natural peptide mimetic of cecropinAnti-infectivePreclinicalHelix Biomedix(Bothell, Washington, USA)
DRAMP18076HB-10719-amino-acid fragment of cecropin BWound healingPreclinicalHelix Biomedix(Bothell, Washington, USA)
DRAMP18077HB-1345Synthetic Lipohexapeptideacne,broad-spectrum antibioticPre-Phase IHelix Biomedix (Bothell, Washington, USA).
DRAMP18078HB1275A lipohexapeptide with potent antifungal activity against yeast and filamentous fungiTrichophyton infectionsPreclinicalHelix Biomedix (Bothell, Washington, USA).
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